NEJM: Antipsychotics really suck

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Lieberman et al. reports the somewhat surprising result that the 2nd generation antipsychotics are only marginally better than the 1st generatio—or rather we should say that they suck marginally less. As someone who hasn't been following this field, what's surprising is how high the discontinuation rate: 74% overall and 64% for the best drug tested: olanzapine. Basically, if you're schizophrenic, the options are not good.

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There just isn't enough money in Schizophrenia.

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