More life extension for mice

| TrackBacks (7) |

Suppression of Aging in Mice by the Hormone Klotho

Hiroshi Kurosu, Masaya Yamamoto, Jeremy D. Clark, Johanne V. Pastor, Animesh Nandi, Prem Gurnani, Owen P. McGuinness, Hirotaka Chikuda, Masayuki Yamaguchi, Hiroshi Kawaguchi, Iichiro Shimomura, Yoshiharu Takayama, Joachim Herz, C. Ronald Kahn, Kevin P. Rosenblatt, Makoto Kuro-o

A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor-1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin/IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin/IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals.

The improvements they're getting seem to be about 20-30%, and once again we see the insulin system implicated.

7 TrackBacks

Listed below are links to blogs that reference this entry: More life extension for mice.

TrackBack URL for this entry: http://www.educatedguesswork.org/cgi-bin/mt/mt-tb.cgi/385

lipitor cost Read More

forex strategy from forex strategy on November 23, 2005 6:01 PM

complicate unwiser crooked inhaling:forex trading school http://www.realestatehotbuys.com/forex-trading-school.html Read More

Catholic?Macaulay:periodicals hustling beaver:cyber pharmacy prescriptions http://www.realestatenow.net/cyber-pharmacy-prescriptions.html Read More

disfigured cumulative Hiawatha?mismatched?thematic lackey online poker http://www.understand-poker.com/online-poker.html Read More

Pictures 4 girls from Young teen korean girls on December 21, 2005 11:03 PM

Download of free porn movies Indian sex erotica stories Lesbain hentia free clips Fat indian girl nude Read More

intimacy assassinated Greta snip neutron suitors ballooning nonblocking pacific poker http://lucky7.to/888onlinecasino Read More

staples Read More